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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1995-2-23
|
| pubmed:abstractText |
Morphine (10 mg/kg, SC) in combination with ICV vehicle induced a significant hyperthermic effect at 120 min (peak time) after injection compared to ICV vehicle plus SC saline (control group). Glibenclamide (50 micrograms, ICV), a selective adenosine triphosphate-sensitive potassium (KATP) channel blocker, in combination with SC saline hardly affected the rectal temperature compared to the control group. ICV glibenclamide antagonized the hyperthermia induced by SC morphine in a dose-dependent manner. From these results, we demonstrated that KATP channels play an important role as modulators of the hyperthermic effect of mu agonists.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0033-3158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
109
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
239-40
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1365664-Adenosine Triphosphate,
pubmed-meshheading:1365664-Animals,
pubmed-meshheading:1365664-Dose-Response Relationship, Drug,
pubmed-meshheading:1365664-Fever,
pubmed-meshheading:1365664-Glyburide,
pubmed-meshheading:1365664-Injections, Intraventricular,
pubmed-meshheading:1365664-Injections, Subcutaneous,
pubmed-meshheading:1365664-Male,
pubmed-meshheading:1365664-Mice,
pubmed-meshheading:1365664-Mice, Inbred Strains,
pubmed-meshheading:1365664-Morphine,
pubmed-meshheading:1365664-Potassium Channels
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice.
|
| pubmed:affiliation |
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|