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pubmed:abstractText |
Female rats were given intragastrically, by means of a probe, Vibramycine in suspension, in a dose 4 mg/kg body weight, in different stages of pregnancy. On kidney sections there were performed: H+E staining, PAS reaction, histochemical determination of enzymes activity: alkaline phosphatase, ATP-ase, SDH and LDH. In non-pregnant females receiving the drug there was observed an intensification of alkaline phosphatase activity in brush border of main tubules of the kidney and a slight broadening of the light of the tubules. In pregnant females receiving the drug, most clearly in the second half of pregnancy a slight intensification of the activity of the examined enzymes was observed.
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