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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-1-27
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pubmed:abstractText |
Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor. A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB-3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3417
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-73
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1361525-Amino Acid Sequence,
pubmed-meshheading:1361525-Blotting, Southern,
pubmed-meshheading:1361525-Cell Line,
pubmed-meshheading:1361525-Chronic Disease,
pubmed-meshheading:1361525-Gene Amplification,
pubmed-meshheading:1361525-Gene Expression,
pubmed-meshheading:1361525-Gene Rearrangement,
pubmed-meshheading:1361525-Humans,
pubmed-meshheading:1361525-Immunohistochemistry,
pubmed-meshheading:1361525-Molecular Sequence Data,
pubmed-meshheading:1361525-Oncogene Proteins v-erbB,
pubmed-meshheading:1361525-Pancreas,
pubmed-meshheading:1361525-Pancreatic Neoplasms,
pubmed-meshheading:1361525-Pancreatitis,
pubmed-meshheading:1361525-Proto-Oncogene Proteins,
pubmed-meshheading:1361525-Receptor, Epidermal Growth Factor,
pubmed-meshheading:1361525-Receptor, erbB-3,
pubmed-meshheading:1361525-Retroviridae Proteins, Oncogenic
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pubmed:year |
1992
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pubmed:articleTitle |
The erbB-3 gene in human pancreatic cancer.
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pubmed:affiliation |
Molecular Pathology Laboratory, Hammersmith Hospital, London, U.K.
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pubmed:publicationType |
Journal Article
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