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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-1-27
pubmed:abstractText
Behavioural, biochemical and histological effects were assessed following AF64A injected into the third ventricle of female NMRI mice. Doses from 3 to 7 nmol produced significant changes in behaviour, causing hyperactivity, reduced hole-board exploration, rotational behaviour in a symmetrical Y-maze corresponding to a loss of alternation, abnormal behaviour in a plus-maze task of fear/anxiety with markedly increased exploration of the open arms and finally deficits in passive avoidance responding and spatial orientation in a Morris-type water maze. In this latter test, a cue learning deficit was noted for the two highest doses only. No histological changes of consequence were observed up to 5 nmol. Beyond this dose, at 6 and particularly 7 nmol, necrosis of parts of the hippocampus and septum was apparent. ChAT and AChE activity were decreased in the hippocampus but not in the cortex although the decreases were smaller than generally reported for AF64A-treated rats. ChAT and AChE reductions correlated highly with hyperactivity in the open-field and to a lesser extent, with spatial learning deficits. Monoaminergic activity was also affected in the hippocampus, but not in the cortex, at 4 nmol and above. NE and particularly 5-HT and 5-HIAA levels were reduced although the rate of 5-HT turnover was unaltered. A highly significant correlation was obtained between 5-HT effects and the increased open arm exploration in the plus-maze task of fear/anxiety. The behavioural effects and biochemical changes lasted at least 8-9 weeks postop.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-77
pubmed:dateRevised
2006-3-1
pubmed:meshHeading
pubmed-meshheading:1361335-Acetylcholinesterase, pubmed-meshheading:1361335-Animals, pubmed-meshheading:1361335-Avoidance Learning, pubmed-meshheading:1361335-Aziridines, pubmed-meshheading:1361335-Behavior, Animal, pubmed-meshheading:1361335-Brain, pubmed-meshheading:1361335-Brain Mapping, pubmed-meshheading:1361335-Choline, pubmed-meshheading:1361335-Choline O-Acetyltransferase, pubmed-meshheading:1361335-Cholinergic Fibers, pubmed-meshheading:1361335-Discrimination Learning, pubmed-meshheading:1361335-Dose-Response Relationship, Drug, pubmed-meshheading:1361335-Escape Reaction, pubmed-meshheading:1361335-Exploratory Behavior, pubmed-meshheading:1361335-Female, pubmed-meshheading:1361335-Frontal Lobe, pubmed-meshheading:1361335-Hippocampus, pubmed-meshheading:1361335-Injections, Intraventricular, pubmed-meshheading:1361335-Learning, pubmed-meshheading:1361335-Memory, pubmed-meshheading:1361335-Mental Recall, pubmed-meshheading:1361335-Mice, pubmed-meshheading:1361335-Mice, Inbred Strains, pubmed-meshheading:1361335-Motor Activity, pubmed-meshheading:1361335-Neurotransmitter Agents, pubmed-meshheading:1361335-Orientation, pubmed-meshheading:1361335-Psychomotor Performance, pubmed-meshheading:1361335-Reflex
pubmed:year
1992
pubmed:articleTitle
Behavioural, biochemical and histological effects of AF64A following injection into the third ventricle of the mouse.
pubmed:affiliation
UCB Pharma, Pharmaceutical Research Center, Braine-l'Alleud, Belgium.
pubmed:publicationType
Journal Article