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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1992-12-1
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pubmed:abstractText |
Cardiac autoantibodies have been detected in a significant proportion of patients with dilated cardiomyopathy, but their relation to the pathogenesis of the disease remains unknown. This issue was examined in 41 members of an Ohio family with a heritable disorder of the cardiac conduction system and the myocardium. In 41.5% of all members studied, serum anti-beta-receptor antibodies were identified by a combination of techniques: ligand binding inhibition assay, enzyme-linked immunoassay of a beta 1-receptor peptide, and adenylate cyclase inhibition. The prevalence of autoantibodies was significantly higher (p < 0.01) in the affected (64.7%) than in the unaffected (25.0%) members. A 10.0 kb restriction fragment length polymorphism of the C beta region of the T-cell receptor gene was also overrepresented in affected males (60% versus 30% unaffected males, p < 0.01). In males, the presence of anti-beta-receptor antibodies was linked to the 10.0 kb C beta polymorphism. In affected males, a BlgII C alpha 2.14 kb polymorphism was also more frequent (62% versus 32% in unaffected, p < 0.01) and was linked to the presence of anti-beta-receptor antibodies. The distribution of haplotypes defined by V beta 8, C alpha, and C beta probes was significantly different between affected and unaffected (p < 0.04) and between antibody-positive and antibody-negative individuals. Since the major function of the T-cell receptor is the recognition of processed autoantigens, these results provide additional support for the role of autoimmunity in dilated cardiomyopathy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0002-8703
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1258-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1359779-Adult,
pubmed-meshheading:1359779-Autoantibodies,
pubmed-meshheading:1359779-Autoimmunity,
pubmed-meshheading:1359779-Cardiomyopathies,
pubmed-meshheading:1359779-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1359779-Family Health,
pubmed-meshheading:1359779-Female,
pubmed-meshheading:1359779-Genes,
pubmed-meshheading:1359779-Haplotypes,
pubmed-meshheading:1359779-Humans,
pubmed-meshheading:1359779-Male,
pubmed-meshheading:1359779-Middle Aged,
pubmed-meshheading:1359779-Polymorphism, Genetic,
pubmed-meshheading:1359779-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1359779-Receptors, Antigen, T-Cell,
pubmed-meshheading:1359779-Receptors, Antigen, T-Cell, alpha-beta
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pubmed:year |
1992
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pubmed:articleTitle |
T-cell receptor gene polymorphisms in familial cardiomyopathy: correlation with anti-beta-receptor autoantibodies.
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pubmed:affiliation |
Department of Laboratory Medicine, University of Minnesota Medical School, Minneapolis 55455.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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