Linked Life Data

1357801

Source:http://linkedlifedata.com/resource/pubmed/id/1357801

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
33
pubmed:dateCreated
1992-11-17
pubmed:abstractText
A review over adrenergic transmembrane signalling in human heart muscle cells, changes in this signalling in patients with heart failure and the influence of medical treatment of heart failure, is presented. In heart failure, the myocardial contractibility is decreased, although the plasma level of catecholamines is elevated. This can be due to changes in the transmembrane signalling. In heart failure, the numbers of beta-receptors are decreased, the amount of Gs-protein is probably unchanged and the amount of Gi-protein is probably increased. Changes in signalling are described in more detail in patients with heart failure based on idiopathic dilated cardiomyopathy (DCM), where a selective down regulation of beta 1-receptors is seen. In heart failure of other origin, there is probably a concomitant reduction in beta 1- and beta 2-receptors. The selective regulation in patients with DCM, can be based on autoantibodies. A 30% reduction in maximal response on selective beta 2 stimulation is additionally seen in patients with DCM, probably based on an increase in the amount of Gi-protein. beta-antagonists increase and beta-agonists decrease the numbers of beta-receptors. The regulation is selective when selective antagonists and agonists are used, and nonselective when nonselective drugs are used. How other drugs affect the transmembrane signalling is still to be elucidated.
pubmed:language
dan
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0041-5782
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2251-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Adrenergic signal transduction in heart failure].
pubmed:affiliation
Medicinsk/kardiologisk afdeling B, Odense Sygehus.
pubmed:publicationType
Journal Article, English Abstract, Review