Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-11-5
pubmed:abstractText
Increased capillary permeability is a central feature of the severe forms of haemorrhagic fever with renal syndrome (HFRS) and occurs also, though less frequently, in nephropathia epidemica (NE), one of the milder forms of this syndrome, caused by Puumala virus. We therefore searched for antiendothelial cell antibodies (AECA) in patients with NE and in those with other presumed or serologically proven acute viral illnesses. By enzyme immunoassay, using human umbilical vein endothelial cells (HUVEC) as the substrate, IgG class AECA were detected significantly more frequently in patients with NE and with influenza A than in Red Cross blood donors. A lesser degree of reactivity could be shown with a human alveolar cell carcinoma line and with human and mouse embryonic fibroblasts. Pretreatment of HUVEC with interferon-gamma (IFN-gamma), but not with IL-1 or tumour necrosis factor-alpha (TNF-alpha), increased their ability to bind IgG of sera from patients with NE and acute febrile illnesses. We conclude that, although AECA can be demonstrated in NE, they occur also in other acute viral illnesses and, unless cytopathic by a mechanism not shared by the AECA of these other illnesses, are unlikely to be casually related to the capillary leak in HFRS.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-1606723, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-1682736, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-1688321, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-175022, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-1974032, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-204432, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2070557, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2112908, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2302834, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2573914, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2574903, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2576470, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2612050, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2741984, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2805426, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2858126, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-2899661, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-3084559, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-3168322, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-3390970, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-345419, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-3491174, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-3518753, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-3742889, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-4355998, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-6102587, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-6111576, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-6151960, http://linkedlifedata.com/resource/pubmed/commentcorrection/1356668-6368583
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-7
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Anti-endothelial cell antibodies in nephropathia epidemica and other viral diseases.
pubmed:affiliation
Department of Bacteriology and Immunology, University of Helsinki, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't