Linked Life Data

1355901

Source:http://linkedlifedata.com/resource/pubmed/id/1355901

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-10-9
pubmed:abstractText
Effects of intracerebroventricular (third ventricle) injection of N-methyl-D-aspartate (NMDA) on arterial blood pressure, on heart rate, on arginine vasopressin (AVP) and levels of catecholamines in plasma and on the behaviour of normotensive freely-moving rats have been evaluated. N-Methyl-D-aspartate significantly (P less than 0.01) increased arterial blood pressure and levels of catecholamines and AVP in plasma. With 0.1-1.0 micrograms/rat all animals presented psychomotor agitation, stereotyped movements, hyperexcitability, exophthalmus, dyspnoea, jumping, rearing and teething. The selective antagonist for NMDA receptors, 2-APV injected in the third ventricle, significantly (P less than 0.01) antagonized the hypertension, the increase in levels of catecholamines and AVP in plasma and behavioural effects. An antagonist of alpha 1 adrenergic receptors, prazosin (i.v.), an agonist of alpha 2 adrenergic receptors, clonidine (i.c.v.) and a relatively selective antagonist of V1 subtype of receptor of AVP, CGP 25838 (i.c.v. and i.v.), 15 min before NMDA, significantly (P less than 0.01) decreased the effects induced by the injections of NMDA. On the contrary, an antagonist of opiate receptors, naloxone (i.v.), 15 min before NMDA, significantly (P less than 0.01) increased the NMDA-induced modifications. Pretreatment with the antagonists at these doses, did not significantly modify the basal values of arterial blood pressure and behaviour. Only 2-APV sometimes induced ataxia, lasting about 5 min. This study points out an increase in the central sympathetic efferent activity and in release of AVP involved in the NMDA-induced cardiovascular and behavioural effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-7
pubmed:dateRevised
2008-8-16
pubmed:meshHeading
pubmed-meshheading:1355901-2-Amino-5-phosphonovalerate, pubmed-meshheading:1355901-Animals, pubmed-meshheading:1355901-Arginine Vasopressin, pubmed-meshheading:1355901-Blood Pressure, pubmed-meshheading:1355901-Cerebral Ventricles, pubmed-meshheading:1355901-Clonidine, pubmed-meshheading:1355901-Dose-Response Relationship, Drug, pubmed-meshheading:1355901-Epinephrine, pubmed-meshheading:1355901-Heart Rate, pubmed-meshheading:1355901-Hypertension, pubmed-meshheading:1355901-Injections, Intravenous, pubmed-meshheading:1355901-Injections, Intraventricular, pubmed-meshheading:1355901-Male, pubmed-meshheading:1355901-N-Methylaspartate, pubmed-meshheading:1355901-Naloxone, pubmed-meshheading:1355901-Norepinephrine, pubmed-meshheading:1355901-Prazosin, pubmed-meshheading:1355901-Rats, pubmed-meshheading:1355901-Rats, Inbred Strains
pubmed:year
1992
pubmed:articleTitle
Participation of arginine vasopressin-mediated and adrenergic system-mediated mechanisms in the hypertension induced by intracerebroventricular administration of NMDA in freely moving rats.
pubmed:affiliation
Institute of Pharmacology and Toxicology, 1st Faculty of Medicine and Surgery, University of Naples Federico II, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't