Linked Life Data

1355656

Source:http://linkedlifedata.com/resource/pubmed/id/1355656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-10-14
pubmed:abstractText
Embryonal carcinoma (EC) cells, the malignant stem cells of teratocarcinomas, resemble early embryonic cells morphologically, developmentally, and with respect to several cell surface characteristics. EC cells often differentiate into a variety of cell types when treated with chemical agents such as retinoic acid, or when placed in a normal embryonic environment. Developmentally regulated surface antigens of EC cells and their differentiated derivatives have been defined using monoclonal antibodies. Many of these "differentiation antigens" have proved to be oligosaccharide chains carried on membrane glycolipids and/or glycoproteins. Our analyses of glycolipid composition in a pluripotent human EC cell line, NTERA-2, have revealed a complex set of glycoslylation changes that occur during cellular differentiation. Like early embryos, undifferentiated NTERA-2 EC cells express predominantly globo-series glycolipids. However, once differentiation is initiated by addition of retinoic acid there is a marked shift of cellular glycolipids from globo-series to lacto- and ganglio-series. Distinct subsets of differentiated cells are characterized by their expression of different patterns of glycolipid antigens. These changes in cell surface phenotype may serve to mark cellular identity and facilitate morphogenetic cell interactions during embryonic development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0903-465X
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-18
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Carbohydrate antigens of embryonal carcinoma cells: changes upon differentiation.
pubmed:affiliation
Department of Pathology and Cell Biology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't