|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1992-10-8
|
|
pubmed:abstractText |
The effects of omeprazole--an inhibitor of gastric acid secretion--on gastrin (G)- and somatostatin (D)-cell density in the gastric antral mucosa epithelium in rats were examined, following a 5-day treatment. It was found that omeprazole increased the density of G-cells, whereas it decreased the density of D-cells. That effect was probably independent of hypergastrinaemia, since it could not be blocked by a simultaneous treatment with proglumide--a gastrin receptor blocker. It is concluded that the observed phenomenon is a direct result of a lower gastric acidity, as a consequence of omeprazole treatment.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0213-3911
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
153-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1355378-Animals,
pubmed-meshheading:1355378-Cell Count,
pubmed-meshheading:1355378-Gastric Mucosa,
pubmed-meshheading:1355378-Gastrins,
pubmed-meshheading:1355378-Immunohistochemistry,
pubmed-meshheading:1355378-Male,
pubmed-meshheading:1355378-Octreotide,
pubmed-meshheading:1355378-Omeprazole,
pubmed-meshheading:1355378-Proglumide,
pubmed-meshheading:1355378-Rats,
pubmed-meshheading:1355378-Rats, Inbred Strains,
pubmed-meshheading:1355378-Somatostatin
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Effects of omeprazole on the number of immunoreactive gastrin- and somatostatin-cells in the rat gastric mucosa.
|
|
pubmed:affiliation |
Department of Experimental Endocrinology and Hormone Diagnostics, University School of Medicine, Lódz, Poland.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
