Linked Life Data

1352505

Source:http://linkedlifedata.com/resource/pubmed/id/1352505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-8-11
pubmed:abstractText
The present study shows that the effects of quinpirole (1 mg/kg) during the second postnatal week but not before resemble the effect of the drug in adult rats in increasing quadruped activity, eliminating grooming, reducing lateral bending, and stimulating verticalized turning. Quinpirole also modifies the morphology of turning behavior, the primary form of coordinated quadruped locomotion in neonate laboratory rat pups. Under saline, turning involves lateral bending and straightening of the trunk. Under quinpirole, turning includes a vertical component of movement ("verticalized turning") instead of the normal lateral bending of the trunk. A similar trend of change in turning is induced by quinpirole in adult rats: An acute injection reduces lateral bending, and a chronic treatment increases verticalization. The induction of vertical turning in the second but not the first postnatal week may stem from the normal course of development since typical vertical movements of intact rats (supported rearing and wall climbing) develop only by the age of 11-14 postnatal days. Verticalized turning may be thus a drug-induced expression of an age-related tendency to perform vertical movements.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0012-1630
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-89
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Quinpirole alters quadruped activity in rats from the second postnatal week.
pubmed:affiliation
Department of Zoology, Tel-Aviv University, Ramat-Aviv, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't