Linked Life Data

1350511

Source:http://linkedlifedata.com/resource/pubmed/id/1350511

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-6-30
pubmed:abstractText
The antigenic profile of basal cell carcinoma (BCC) cells was analyzed by immunoperoxidase staining of 27 surgically removed BCC lesions with antiganglioside, antiadhesion molecule, and antihistocompatibility locus antigen (HLA) monoclonal antibodies (MoAb). The large majority of BCC lesions were stained by antiganglioside MoAb; among the latter the anti-GD3 ganglioside MoAb R24 displayed the broadest reactivity. The GD3 ganglioside expression by BCC cells, which was corroborated by thin layer chromatography immunostaining with MoAb R24, appears to be a proliferation dependent phenomenon. Among the adhesion molecules tested vitronectin receptor and CDw44 were found in up to 70% of the lesions tested, while intercellular adhesion molecule 1 (ICAM-1) was detected in only a low percentage of BCC cells in one lesion. ICAM-1 was not induced on BCC cells in five and three lesions removed 24 and 48 h, respectively, following the intralesional injection of gamma-interferon. The latter enhanced HLA Class I antigen expression and induced ICAM-1 expression by the surrounding keratinocytes; furthermore gamma-interferon induced HLA Class II antigen expression by a small percentage of BCC cells in three lesions. These results suggest that malignant transformation of keratinocytes is associated with a selective loss of susceptibility to induction by cytokines of ICAM-1 expression. Besides confirming the low HLA Class I and Class II antigen expression by BCC cells, the present investigation has shown a differential expression of distinct monomorphic determinants of HLA Class I antigens and a lower expression of HLA-A antigens than of HLA-B antigens by BCC cells. Furthermore, the present study has shown that HLA Class II antigens can be induced on BCC cells by cytokines.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3201-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:1350511-Aged, pubmed-meshheading:1350511-Antibodies, Monoclonal, pubmed-meshheading:1350511-Antibody Specificity, pubmed-meshheading:1350511-Antigens, CD, pubmed-meshheading:1350511-Carcinoma, Basal Cell, pubmed-meshheading:1350511-Cell Adhesion Molecules, pubmed-meshheading:1350511-Chromatography, Thin Layer, pubmed-meshheading:1350511-Female, pubmed-meshheading:1350511-Gangliosides, pubmed-meshheading:1350511-HLA Antigens, pubmed-meshheading:1350511-HLA-D Antigens, pubmed-meshheading:1350511-Histocompatibility Antigens Class I, pubmed-meshheading:1350511-Humans, pubmed-meshheading:1350511-Immunoenzyme Techniques, pubmed-meshheading:1350511-Intercellular Adhesion Molecule-1, pubmed-meshheading:1350511-Interferon-gamma, pubmed-meshheading:1350511-Lymphocytes, Tumor-Infiltrating, pubmed-meshheading:1350511-Male, pubmed-meshheading:1350511-Skin Neoplasms, pubmed-meshheading:1350511-T-Lymphocytes, Cytotoxic
pubmed:year
1992
pubmed:articleTitle
Ganglioside, adhesion molecule, and HLA antigen expression in basal cell carcinoma lesions.
pubmed:affiliation
Department of Dermatology, Kumamoto University Medical School, Japan.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.