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In the Rat, desensitization to noradrenaline induced by perfusion of large doses of noradrenaline (0.5 to 0.75 mug/mn/100 g), is not suppressed by indomethacine (1 to 5 mg/100 g). Synthesis and release of endogenous prostaglandins of the PGE group are not the cause of the desensitization.
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