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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-4-22
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| pubmed:abstractText |
The purpose of the present study was two-fold. Firstly, to present a more comprehensive analysis of the disinhibitory effects of 5-HT1A receptor agonists after discrete dorsal raphe (DRN) injections (Higgins et al. 1988). Secondly, the effects of the 5-HT1B receptor agonist CGS12066B and the 5-HT1B/1C agonist mCPP were examined following injection into this nucleus. The increases in social interaction (SI) induced by intra-raphe injections of 8-OH DPAT (0.02-1 micrograms), buspirone (0.04-0.2 microgram), ipsapirone (0.2 microgram) and gepirone (0.2-1 micrograms) under a high light unfamiliar paradigm (HLU) were typically due to increased bout frequency, duration and a higher incidence of sniff, follow, allogroom behaviour. These increases were qualitatively similar to those seen in control animals tested under low light/familiar (LLF) conditions, thus supporting the belief that the drug-induced increases in SI reflected decreases in anxiety. Furthermore, at doses effective under the HLU condition, 8-OH DPAT, buspirone and gepirone failed to modify SI under conditions of minimal suppression (LLF paradigm). At doses which significantly increased punished responding in a water-lick conflict test 8-OH DPAT, ipsapirone and gepirone tended to also increase unpunished rates of drinking. However, in drug untreated rats, prior habituation to the test apparatus also increased unpunished drinking, suggesting some neophobia-induced suppression. At a comparatively high dose, the 5-HT1B agonist CGS12066B (2.5 micrograms), but not the putative 5-HT1B/1C agonist mCPP (0.5-12.5 micrograms), increased SI under the HLU condition.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(2-carboxypiperazin-4-yl)propyl-1-...,
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CGS 12066B,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydronaphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/gepirone
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0033-3158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
106
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
261-7
|
| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:1347954-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:1347954-Animals,
pubmed-meshheading:1347954-Anti-Anxiety Agents,
pubmed-meshheading:1347954-Anxiety,
pubmed-meshheading:1347954-Conflict (Psychology),
pubmed-meshheading:1347954-Injections,
pubmed-meshheading:1347954-Interpersonal Relations,
pubmed-meshheading:1347954-Male,
pubmed-meshheading:1347954-Microinjections,
pubmed-meshheading:1347954-Piperazines,
pubmed-meshheading:1347954-Pyrimidines,
pubmed-meshheading:1347954-Quinoxalines,
pubmed-meshheading:1347954-Raphe Nuclei,
pubmed-meshheading:1347954-Rats,
pubmed-meshheading:1347954-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:1347954-Receptors, Serotonin,
pubmed-meshheading:1347954-Tetrahydronaphthalenes
|
| pubmed:year |
1992
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| pubmed:articleTitle |
Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection.
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| pubmed:affiliation |
Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Herts, UK.
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| pubmed:publicationType |
Journal Article
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