Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9 Suppl 14
|
| pubmed:dateCreated |
1994-10-19
|
| pubmed:abstractText |
T-cell clones derived from the CSF (cerebrospinal fluid) of MS (multiple sclerosis) patients have been analysed for the production of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). Each CSF-T clone (both CD4+ and CD8+) produced substantial amounts of IFN-gamma and especially TNF-alpha compared with autologous peripheral T clones and liver-infiltrating T clones from patients with chronic active hepatitis. The large quantities of TNF produced by CSF-T cell clones suggest an important role for this cytokine in MS immunopathogenesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0392-0461
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
79-83
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:1345744-Adult,
pubmed-meshheading:1345744-Cerebrospinal Fluid,
pubmed-meshheading:1345744-Clone Cells,
pubmed-meshheading:1345744-Female,
pubmed-meshheading:1345744-Humans,
pubmed-meshheading:1345744-Interferon-gamma,
pubmed-meshheading:1345744-Interleukin-2,
pubmed-meshheading:1345744-Interleukin-4,
pubmed-meshheading:1345744-Multiple Sclerosis,
pubmed-meshheading:1345744-T-Lymphocytes,
pubmed-meshheading:1345744-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis.
|
| pubmed:affiliation |
Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma.
|
| pubmed:publicationType |
Journal Article
|