Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-1-6
pubmed:abstractText
A series of 60 gastric endocrine tumors comprised 44 body-fundus argyrophil carcinoids, of which 23 arose in a background of hypergastrinemia and type A chronic atrophic gastritis (A-CAG), mainly with histologic patterns suggestive of an autoimmune process. Only 22 percent (compared with 19 percent of 58 tumor-free A-CAG cases) of 36 carcinoids and 21 percent of 19 A-CAG carcinoids investigated had Helicobacter pylori (HP) colonization, against 50 percent of 14 CAG-associated neuroendocrine carcinomas or mixed endocrine-exocrine tumors, 84 percent of 150 cases with early gastric cancer (p < 0.001 versus carcinoids), mostly with B- or AB-type CAG, 76 percent of 97 tumor-free AB-CAG, and 95 percent of 151 tumor-free B-CAG cases. Secondary hypergastrinemia and local mechanisms activated by chronic autoimmune gastritis are among factors involved in the pathogenesis of relatively indolent CAG-associated carcinoids, whereas active HP gastritis in cooperation with environmental carcinogens may likely cause more severe epithelial transformation, leading to ordinary cancer and, possibly, to neuroendocrine carcinomas or mixed endocrine-exocrine tumors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1675024, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1702355, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1715667, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1759123, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1891020, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1891021, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1970928, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-1985029, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2023282, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2044906, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2210881, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2253822, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2312104, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2422953, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2578420, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2644152, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2653970, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2715350, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-2776113, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-3072229, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-3338059, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-3350978, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-3409251, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-3525475, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-3539679, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-3952448, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-4023614, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-4024941, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-4762929, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-6083970, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-6197001, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-6618097, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-6692375, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-6777102, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-6883274, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-6888429, http://linkedlifedata.com/resource/pubmed/commentcorrection/1341079-7350846
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-0086
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
793-804; discussion 827-9
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:articleTitle
Distinct patterns of chronic gastritis associated with carcinoid and cancer and their role in tumorigenesis.
pubmed:affiliation
Department of Human Pathology and Genetics, I Medical Faculty, University of Pavia, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't