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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-1-6
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pubmed:abstractText |
Previous in vivo and in vitro studies from our laboratory have revealed a line of pharmacological evidence supporting histamine H3 receptor(s) involvement in the control of gastric acid secretion. We have recently extended our studies to the human gastric tumoral cell HGT-1. This cell was found to contain an H3 receptor inhibiting basal and carbachol-stimulated inositol phosphate formation. Furthermore, we were able to solubilize and affinity-purify this receptor in the form of a single 70 kDa protein. These findings are the first biochemical description of the H3 receptor subtype and the first direct demonstration that this subtype can occur on a non-neural cell. Furthermore, they provide a molecular basis to explain its suggested inhibitory role in gastric physiology.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-1334091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-1370748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-14045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-1660330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-1850206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-1904297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-2164693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-2470453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-2882563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-6188956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-6277484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-77328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1341067-894608
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0044-0086
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
607-11; discussion 621-3
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
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pubmed:articleTitle |
The gastric H3 receptor: a review.
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pubmed:affiliation |
INSERM, Hôpital Bichat, Paris, France.
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pubmed:publicationType |
Journal Article,
Review
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