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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1993-3-15
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pubmed:abstractText |
Two potent glutamate antagonists, NBQX and GYKI 52466, that act selectively on non-NMDA receptors, have been tested for anticonvulsant activity in 3 models of reflex epilepsy (sound-induced seizures in DBA/2 mice and in genetically epilepsy-prone rats and photically-induced myoclonus in Papio papio) and in amygdala kindled rats. Both compounds potently but transiently suppress reflexly-induced epileptic responses. GYKI 52466 also reduces behavioral seizures and afterdischarge duration in amygdala kindled rats, but with a lower potency than it suppresses reflex epilepsy. These data are similar to earlier results with antagonists acting selectively on NMDA receptors; they do not support a specific involvement of enhanced AMPA receptor sensitivity as a major factor in the expression of kindled seizures.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3-dioxo-6-nitro-7-sulfamoylbenzo(f...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GYKI 52466,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate
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pubmed:status |
MEDLINE
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pubmed:issn |
0922-9833
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-11
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1337444-Acoustic Stimulation,
pubmed-meshheading:1337444-Amygdala,
pubmed-meshheading:1337444-Animals,
pubmed-meshheading:1337444-Anti-Anxiety Agents,
pubmed-meshheading:1337444-Anticonvulsants,
pubmed-meshheading:1337444-Benzodiazepines,
pubmed-meshheading:1337444-Cerebral Cortex,
pubmed-meshheading:1337444-Electroencephalography,
pubmed-meshheading:1337444-Epilepsies, Myoclonic,
pubmed-meshheading:1337444-Epilepsy,
pubmed-meshheading:1337444-Evoked Potentials,
pubmed-meshheading:1337444-Excitatory Amino Acid Antagonists,
pubmed-meshheading:1337444-Hippocampus,
pubmed-meshheading:1337444-Kindling, Neurologic,
pubmed-meshheading:1337444-Mice,
pubmed-meshheading:1337444-Mice, Inbred DBA,
pubmed-meshheading:1337444-Neural Pathways,
pubmed-meshheading:1337444-Papio,
pubmed-meshheading:1337444-Photic Stimulation,
pubmed-meshheading:1337444-Quinoxalines,
pubmed-meshheading:1337444-Rats,
pubmed-meshheading:1337444-Rats, Inbred Strains,
pubmed-meshheading:1337444-Receptors, AMPA,
pubmed-meshheading:1337444-Receptors, Glutamate,
pubmed-meshheading:1337444-Reflex,
pubmed-meshheading:1337444-Synaptic Transmission
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pubmed:year |
1992
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pubmed:articleTitle |
The effects of AMPA receptor antagonists on kindled seizures and on reflex epilepsy in rodents and primates.
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pubmed:affiliation |
Department of Neurology, Institute of Psychiatry, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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