Linked Life Data

1336343

Source:http://linkedlifedata.com/resource/pubmed/id/1336343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1993-2-9
pubmed:abstractText
The increasing emergence of penicillin-resistant and multiresistant strains of Streptococcus pneumoniae may pose a problem in coming years. We therefore compared sparfloxacin, a new fluoroquinolone with improved potency against streptococci, with amoxicillin, the "gold standard" in this setting, and another fluoroquinolone, ciprofloxacin, in a mouse pneumonia model. Their efficacies against penicillin-susceptible (serotype 3), macrolide-resistant (serotype 1), penicillin-resistant (serotype 23), and multiresistant (serotype 6) S. pneumoniae strains were evaluated. Immunocompetent Swiss mice (serotypes 1 and 3) and leukopenic mice (serotypes 6 and 23) were infected by peroral tracheal delivery of 10(4) to 10(6) CFU. Subcutaneous injections of antibiotics were initiated at 6, 18, 48, or 72 h after infection (six injections at 12-h intervals). In the immunocompetent mice, 100% survival was obtained with sparfloxacin (50 mg/kg) and amoxicillin (5 mg/kg) against both penicillin-susceptible and macrolide-resistant strains; ciprofloxacin gave significantly lower survival rates. Two to four injections of sparfloxacin completely cleared bacteria from lungs and blood; the most rapid eradication was achieved with amoxicillin. Sparfloxacin also fully protected leukopenic mice against penicillin-resistant strains. The dose of amoxicillin (50 mg/kg) required to protect mice and eradicate penicillin-resistant and multiresistant strains was 10 times higher than that effective against penicillin-susceptible strains. The microbiological and pharmacokinetic properties of sparfloxacin (e.g., the time during which concentrations exceed the MIC of the test pathogen) accounted for its efficacy against susceptible and resistant strains of S. pneumoniae in this model.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-1160938, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-1729176, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-1787127, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-1988515, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-2112467, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-2187594, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-2327763, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-2393270, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-2558617, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-2802544, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-3275531, http://linkedlifedata.com/resource/pubmed/commentcorrection/1336343-3587309
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2698-703
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
In vivo efficacy of a new fluoroquinolone, sparfloxacin, against penicillin-susceptible and -resistant and multiresistant strains of Streptococcus pneumoniae in a mouse model of pneumonia.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale U.13, Hôpital Claude Bernard, Paris, France.
pubmed:publicationType
Journal Article, Comparative Study