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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-2-10
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pubmed:databankReference |
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pubmed:abstractText |
Degenerate DNA oligomers coding for highly conserved regions of the voltage-gated calcium channel were synthesized for the polymerase chain reaction (PCR) using DNA from a human brain cDNA library as template. PCR amplified a 640-bp DNA fragment from the human brain cDNA library. Sequencing revealed that this fragment encodes part of a protein highly homologous to a subtype of the dihydropyridine-sensitive calcium channel cloned from rabbit heart and rat brain. Southern analysis of panels of somatic cell hybrids mapped the 640-bp fragment, CACNL1A1, to human chromosome 12p13-pter.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:geneSymbol |
CACNL1A1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1092-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1335957-Amino Acid Sequence,
pubmed-meshheading:1335957-Animals,
pubmed-meshheading:1335957-Base Sequence,
pubmed-meshheading:1335957-Blotting, Southern,
pubmed-meshheading:1335957-Brain,
pubmed-meshheading:1335957-Calcium Channels,
pubmed-meshheading:1335957-Calcium Channels, L-Type,
pubmed-meshheading:1335957-Chromosome Mapping,
pubmed-meshheading:1335957-Chromosomes, Human, Pair 12,
pubmed-meshheading:1335957-Cricetinae,
pubmed-meshheading:1335957-DNA,
pubmed-meshheading:1335957-Humans,
pubmed-meshheading:1335957-Hybrid Cells,
pubmed-meshheading:1335957-Ion Channel Gating,
pubmed-meshheading:1335957-Molecular Sequence Data,
pubmed-meshheading:1335957-Nerve Tissue Proteins,
pubmed-meshheading:1335957-Polymerase Chain Reaction
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pubmed:year |
1992
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pubmed:articleTitle |
Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter.
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pubmed:affiliation |
Department of Biology, University of California San Diego, La Jolla 92093-0319.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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