| pubmed-article:1332592 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1332592 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:1332592 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:1332592 | lifeskim:mentions | umls-concept:C0042774 | lld:lifeskim |
| pubmed-article:1332592 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1332592 | lifeskim:mentions | umls-concept:C0072261 | lld:lifeskim |
| pubmed-article:1332592 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1332592 | pubmed:dateCreated | 1992-12-18 | lld:pubmed |
| pubmed-article:1332592 | pubmed:abstractText | We have investigated the direct effect of dimethyl prostaglandin A1 (dmPGA1) on the replication of herpes simplex virus (HSV) and human immunodeficiency virus type 1 (HIV-1). dmPGA1 significantly inhibited viral replication in both HSV and HIV infection systems at concentrations of dmPGA1 that did not adversely alter cellular DNA synthesis. The 50% inhibitory concentration (ID50) for several HSV type 1 (HSV-1) strains ranged from 3.8 to 5.6 micrograms/ml for Vero cells and from 4.6 to 7.3 micrograms/ml for human foreskin fibroblasts. The ID50s for two HSV-2 strains varied from 3.8 to 4.5 micrograms/ml for Vero cells; the ID50 was 5.7 micrograms/ml for human foreskin fibroblasts. We found that closely related prostaglandins did not have the same effect on the replication of HSV; dmPGE2 and dmPGA2 caused up to a 60% increase in HSV replication compared with that in untreated virus-infected cells. HIV-1 replication in acutely infected T cells (VB line) and chronically infected macrophages was assessed by quantitative decreases in p24 concentration. The effective ID50s were 2.5 micrograms/ml for VB cells acutely infected with HIV-1 and 5.2 micrograms/m for chronically infected macrophages. dmPGA1 has an unusual broad-spectrum antiviral activity against both HSV and HIV-1 in vitro and offers a new class of potential therapeutic agents for in vivo use. | lld:pubmed |
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| pubmed-article:1332592 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1332592 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332592 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1332592 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1332592 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1332592 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:1332592 | pubmed:author | pubmed-author:PulliamLL | lld:pubmed |
| pubmed-article:1332592 | pubmed:author | pubmed-author:EricksonSS | lld:pubmed |
| pubmed-article:1332592 | pubmed:author | pubmed-author:McGrathM SMS | lld:pubmed |
| pubmed-article:1332592 | pubmed:author | pubmed-author:HankaRR | lld:pubmed |
| pubmed-article:1332592 | pubmed:author | pubmed-author:Hughes-Fulfor... | lld:pubmed |
| pubmed-article:1332592 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1332592 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:1332592 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1332592 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1332592 | pubmed:pagination | 2253-8 | lld:pubmed |
| pubmed-article:1332592 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1332592 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1332592 | pubmed:articleTitle | Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. | lld:pubmed |
| pubmed-article:1332592 | pubmed:affiliation | Research Service, Veterans Administration Medical Center, San Francisco, California 94121. | lld:pubmed |
| pubmed-article:1332592 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1332592 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1332592 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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