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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1992-12-18
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pubmed:abstractText |
We have investigated the direct effect of dimethyl prostaglandin A1 (dmPGA1) on the replication of herpes simplex virus (HSV) and human immunodeficiency virus type 1 (HIV-1). dmPGA1 significantly inhibited viral replication in both HSV and HIV infection systems at concentrations of dmPGA1 that did not adversely alter cellular DNA synthesis. The 50% inhibitory concentration (ID50) for several HSV type 1 (HSV-1) strains ranged from 3.8 to 5.6 micrograms/ml for Vero cells and from 4.6 to 7.3 micrograms/ml for human foreskin fibroblasts. The ID50s for two HSV-2 strains varied from 3.8 to 4.5 micrograms/ml for Vero cells; the ID50 was 5.7 micrograms/ml for human foreskin fibroblasts. We found that closely related prostaglandins did not have the same effect on the replication of HSV; dmPGE2 and dmPGA2 caused up to a 60% increase in HSV replication compared with that in untreated virus-infected cells. HIV-1 replication in acutely infected T cells (VB line) and chronically infected macrophages was assessed by quantitative decreases in p24 concentration. The effective ID50s were 2.5 micrograms/ml for VB cells acutely infected with HIV-1 and 5.2 micrograms/m for chronically infected macrophages. dmPGA1 has an unusual broad-spectrum antiviral activity against both HSV and HIV-1 in vitro and offers a new class of potential therapeutic agents for in vivo use.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-212521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-2426284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-2536171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-2704750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-2813398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3010301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3030346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3036736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3040001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3162731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3198648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3456266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-3924371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6157190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6185627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6198441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6244226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6289665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6294110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6572555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1332592-6606682
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2253-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1332592-Animals,
pubmed-meshheading:1332592-Antiviral Agents,
pubmed-meshheading:1332592-Cell Line,
pubmed-meshheading:1332592-Cells, Cultured,
pubmed-meshheading:1332592-Cercopithecus aethiops,
pubmed-meshheading:1332592-Fibroblasts,
pubmed-meshheading:1332592-HIV,
pubmed-meshheading:1332592-Humans,
pubmed-meshheading:1332592-Macrophages,
pubmed-meshheading:1332592-Prostaglandins A, Synthetic,
pubmed-meshheading:1332592-Simplexvirus,
pubmed-meshheading:1332592-Vero Cells,
pubmed-meshheading:1332592-Virus Replication
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pubmed:year |
1992
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pubmed:articleTitle |
Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication.
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pubmed:affiliation |
Research Service, Veterans Administration Medical Center, San Francisco, California 94121.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
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