Linked Life Data

1324086

Source:http://linkedlifedata.com/resource/pubmed/id/1324086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-9-24
pubmed:abstractText
We report here the effects of pinealectomy and light exposure on the melatonin receptor density in the pars tuberalis of the rat and the European hamster using quantitative autoradiography. Scatchard analysis revealed that 24 and 72 h of constant light exposure (LL) before sacrifice did not modify the Kd value of melatonin for its receptors in rats and European hamsters (about 70 pM). In contrast, the Bmax value was significantly increased in both species when the animals were kept in constant illumination for 72 h before sacrifice (50%-70% compared with the controls). A similar increase was also observed in rats pinealectomized 3 days before sacrifice and then kept in either constant illumination or in 12L/12D. Pinealectomy or constant light exposure are known to result in a clear decrease in the concentration of circulating melatonin. We demonstrate here that they also result in an increase in the density of melatonin receptors. This could suggest a direct effect of melatonin on its own receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
575
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Pinealectomy and constant illumination increase the density of melatonin binding sites in the pars tuberalis of rodents.
pubmed:affiliation
Neurobiologie des fonctions rythmiques et saisonnières, URA-CNRS 1332, Université Louis Pasteur, Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't