Linked Life Data

1320710

Source:http://linkedlifedata.com/resource/pubmed/id/1320710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-8-12
pubmed:abstractText
Mercuric chloride (HgCl2) induces an autoimmune syndrome in Brown Norway (BN) rats characterized by the presence of a number of autoantibodies, including antibodies to glomerular basement membrane. Tissue injury has previously been reported to be rare in this model, but in the accompanying paper we describe changes in a number of organs including a necrotizing leucocytoclastic vasculitis in the gut. Myeloperoxidase (MPO) is one of the target antigens for anti-neutrophil cytoplasm antibodies, that are present in the majority of patients with the human autoimmune disease systemic vasculitis and have been implicated in pathogenesis. There is at present, no animal model for anti-neutrophil cytoplasm antibody positive systemic vasculitis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-20
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Autoantibodies to myeloperoxidase in brown Norway rats treated with mercuric chloride.
pubmed:affiliation
Department of Medicine, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't