rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1992-8-6
|
pubmed:abstractText |
Potent analgesia is elicited by electrical stimulation of the periaqueductal gray (PAG), dorsal raphe nucleus (DRN) and intralaminar thalamus. Horseradish peroxidase conjugated wheat germ agglutinin (HRP-WGA) was stereotaxically pressure injected into the parafascicular (PF) or central medial (CM) nucleus to identify brainstem afferents to the intralaminar thalamus. WGA-immunoreactive (-ir) neurons were identified in the DRN, PAG and lateral dorsal tegmentum (LDTg) after PF and CM injections. Many retrogradely labeled cells in the DRN and ventral PAG were also serotonin-ir, and a portion of WGA-ir cells in the LDTg were substance P-ir. These results substantiate previous studies implicating the intralaminar thalamus and periaqueductal region, as well as serotonin and substance P, in antinociception.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0196-9781
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
171-6
|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1320263-Animals,
pubmed-meshheading:1320263-Histocytochemistry,
pubmed-meshheading:1320263-Male,
pubmed-meshheading:1320263-Neurons, Afferent,
pubmed-meshheading:1320263-Pain,
pubmed-meshheading:1320263-Rats,
pubmed-meshheading:1320263-Rats, Inbred Strains,
pubmed-meshheading:1320263-Receptors, Mitogen,
pubmed-meshheading:1320263-Receptors, Neurokinin-1,
pubmed-meshheading:1320263-Receptors, Neurotransmitter,
pubmed-meshheading:1320263-Receptors, Serotonin,
pubmed-meshheading:1320263-Thalamic Nuclei,
pubmed-meshheading:1320263-Wheat Germ Agglutinins
|
pubmed:articleTitle |
Serotonin and substance P afferents to parafascicular and central medial nuclei.
|
pubmed:affiliation |
Neuroendocrine Unit, University of Rochester School of Medicine, NY 14642.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|