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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-8-6
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pubmed:abstractText |
In the airways, activation of histamine H3-receptors with (R)-alpha-methylhistamine inhibits neurally induced cholinergic contractions in vitro and peptidergic responses in vivo. The role of histamine H3-receptors on the cholinergic bronchoconstriction induced by electrical stimulation of the dorsal medulla in guinea pigs was assessed in this study. There was no evidence for an H3-receptor mediated inhibition of cholinergic bronchospasm in vivo. However, there was potentiation of central cholinergic bronchoconstriction by (R)-alpha-methylhistamine or histamine by a mechanism involving H1-receptors. I.v. (R)-alpha-methylhistamine (0.3-3 mg/kg) or histamine (0.001-0.01 mg/kg) produced a transient bronchospasm and potentiated the bronchoconstriction due to medullary stimulation. These effects of (R)-alpha-methylhistamine and histamine were blocked by the histamine H1-antagonist, chlorpheniramine (30 micrograms/kg i.v.) but not by H2- or H3-receptor antagonists. (R)-alpha-Methyl-histamine did not potentiate the bronchoconstriction due to i.v. methacholine. Other bronchoconstrictor agents such as methacholine and serotonin did not potentiate the CNS-induced bronchospasm.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
211
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1319915-Animals,
pubmed-meshheading:1319915-Bronchial Spasm,
pubmed-meshheading:1319915-Bronchoconstriction,
pubmed-meshheading:1319915-Central Nervous System,
pubmed-meshheading:1319915-Chlorpheniramine,
pubmed-meshheading:1319915-Cholinergic Fibers,
pubmed-meshheading:1319915-Electric Stimulation,
pubmed-meshheading:1319915-Guinea Pigs,
pubmed-meshheading:1319915-Histamine,
pubmed-meshheading:1319915-Lung,
pubmed-meshheading:1319915-Male,
pubmed-meshheading:1319915-Medulla Oblongata,
pubmed-meshheading:1319915-Methylhistamines,
pubmed-meshheading:1319915-Parasympathetic Nervous System,
pubmed-meshheading:1319915-Receptors, Histamine,
pubmed-meshheading:1319915-Receptors, Histamine H1,
pubmed-meshheading:1319915-Receptors, Histamine H3,
pubmed-meshheading:1319915-Synaptic Transmission,
pubmed-meshheading:1319915-Trachea
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pubmed:year |
1992
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pubmed:articleTitle |
(R)-alpha-methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation.
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pubmed:affiliation |
Schering-Plough Research, Bloomfield, NJ 07003.
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pubmed:publicationType |
Journal Article
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