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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1992-6-26
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pubmed:abstractText |
We assessed the correlation between the positivity for serum IgM antibody to hepatitis C virus and the activity of liver disease in patients with chronic hepatitis C virus infection. Serum samples were taken from 10 antibody to hepatitis C virus-positive asymptomatic patients with normal serum ALT levels, from 14 untreated patients with clinically and histologically proven chronic hepatitis C and from 26 patients with clinically and histologically proven chronic hepatitis C assigned to receive recombinant interferon alpha-2a (6 million IU three times a week for 6 mo). Each serum specimen was tested for IgM antibody to hepatitis C virus-associated C100-3 antigen by enzyme-linked immunosorbent assay. Patients were observed for at least 12 mo. All 10 patients with normal ALT values tested negative for IgM antibody to hepatitis C virus. In contrast, 33 of 40 (82%) patients with chronic hepatitis C had IgM antibody to hepatitis C virus, and a positive correlation was seen between the ALT level and the level of IgM antibody to hepatitis C virus (r = 0.803, p less than 0.001). During interferon treatment, ALT levels declined into the normal range in 18 of 26 treated patients (69%) and remained normal after stopping treatment in 8 patients (31%). In untreated patients, in treated patients who did not respond to interferon treatment and in responder patients who relapsed, no significant changes in IgM antibody to hepatitis C virus levels were seen during the study period. In contrast, IgM antibody to hepatitis C virus became undetectable by the end of interferon treatment in seven of eight patients with a sustained response.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/C100 protein, hepatitis C virus,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Nonstructural Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2a
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
998-1001
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1317344-Adult,
pubmed-meshheading:1317344-Antigens, Viral,
pubmed-meshheading:1317344-Chronic Disease,
pubmed-meshheading:1317344-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1317344-Female,
pubmed-meshheading:1317344-Hepacivirus,
pubmed-meshheading:1317344-Hepatitis Antibodies,
pubmed-meshheading:1317344-Hepatitis C,
pubmed-meshheading:1317344-Humans,
pubmed-meshheading:1317344-Immunoglobulin M,
pubmed-meshheading:1317344-Interferon-alpha,
pubmed-meshheading:1317344-Male,
pubmed-meshheading:1317344-Middle Aged,
pubmed-meshheading:1317344-Recombinant Proteins,
pubmed-meshheading:1317344-Viral Nonstructural Proteins,
pubmed-meshheading:1317344-Viral Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Significance of IgM antibody to hepatitis C virus in patients with chronic hepatitis C.
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pubmed:affiliation |
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.
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pubmed:publicationType |
Journal Article
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