| pubmed-article:1315448 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C1707524 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C1720886 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C0071163 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C1157645 | lld:lifeskim |
| pubmed-article:1315448 | lifeskim:mentions | umls-concept:C1709366 | lld:lifeskim |
| pubmed-article:1315448 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1315448 | pubmed:dateCreated | 1992-6-4 | lld:pubmed |
| pubmed-article:1315448 | pubmed:abstractText | The present study was aimed at investigating whether PACAP stimulates accumulation of cAMP, as well as hormonal secretion of homogeneous populations of pituitary proopiomelanocortin (POMC) cells, namely melanotrophs and AtT-20 corticotrophs. PACAP was shown to enhance cAMP accumulation in a dose-dependent fashion in both cell types (with EC50 values of approx. 10(-10) M) and elicited additive increases of cAMP production with CRF in melanotrophs, but not in corticotrophs. PACAP also stimulated dose-dependently the secretion of alpha-MSH and ACTH, with EC50 concentrations of about 10(-9) M. In melanotrophs, bromocriptine significantly depressed PACAP-induced cAMP formation and blunted by more than 90% stimulated alpha-MSH release. This study shows that (1) pituitary POMC cells did respond to PACAP by enhancing cAMP accumulation and elevating hormone secretion as well; (2) the effect of PACAP was additive with CRF on cAMP production in melanotrophs, but not in corticotrophs, while there was no additivity on peptide output from both cell types; (3) activation of dopamine receptors in melanotrophs dampened both cAMP formation and peptide secretion. These findings are consistent with PACAP playing a possible hypophysiotropic role in the regulation of pituitary POMC cell activity. | lld:pubmed |
| pubmed-article:1315448 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1315448 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1315448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315448 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1315448 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1315448 | pubmed:issn | 0167-0115 | lld:pubmed |
| pubmed-article:1315448 | pubmed:author | pubmed-author:KochBB | lld:pubmed |
| pubmed-article:1315448 | pubmed:author | pubmed-author:Lutz-BucherBB | lld:pubmed |
| pubmed-article:1315448 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1315448 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:1315448 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:1315448 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1315448 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1315448 | pubmed:pagination | 45-53 | lld:pubmed |
| pubmed-article:1315448 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
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| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:meshHeading | pubmed-meshheading:1315448-... | lld:pubmed |
| pubmed-article:1315448 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1315448 | pubmed:articleTitle | Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates cyclic AMP formation as well as peptide output of cultured pituitary melanotrophs and AtT-20 corticotrophs. | lld:pubmed |
| pubmed-article:1315448 | pubmed:affiliation | Laboratoire de Physiologie, URA CNRS 1446, Université L. Pasteur, Strasbourg, France. | lld:pubmed |
| pubmed-article:1315448 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1315448 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1315448 | lld:pubmed |
