| pubmed-article:1314824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1314824 | lifeskim:mentions | umls-concept:C0017742 | lld:lifeskim |
| pubmed-article:1314824 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1314824 | lifeskim:mentions | umls-concept:C1327287 | lld:lifeskim |
| pubmed-article:1314824 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1314824 | lifeskim:mentions | umls-concept:C0171244 | lld:lifeskim |
| pubmed-article:1314824 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1314824 | pubmed:dateCreated | 1992-5-28 | lld:pubmed |
| pubmed-article:1314824 | pubmed:abstractText | Tumor necrosis factor alpha (TNF alpha), 12-O-tetradecanoylphorbol-13-acetate and cAMP stimulate hexose transport in quiescent 3T3-L1 preadipocytes by stabilizing the relatively labile mRNA coding for the basal glucose transporter, GLUT-1. The 3'-UTR of GLUT-1 mRNA contains a single copy of the destabilizing AUUUA motif in the context of an AU-rich region. The adenosine-uridine binding factor (AUBF) is a cytosolic protein which interacts with similar AU-rich regions in a variety of labile cytokine and oncogene mRNAs. Here, we demonstrate that AUBF complexes in vitro with GLUT-1 mRNA through the AU-rich portion of the 3'-UTR. AUBF activity is very low in quiescent preadipocytes, but can be up-regulated by agonists such as TPA, TNF alpha, cAMP, and okadaic acid, all of which stabilize GLUT-1 mRNA. The time courses of TNF alpha- and TPA-mediated AUBF up-regulation and GLUT-1 mRNA stabilization are coincident, suggesting a cause and effect relationship. | lld:pubmed |
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| pubmed-article:1314824 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1314824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314824 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1314824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1314824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1314824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1314824 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1314824 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1314824 | pubmed:author | pubmed-author:PekalaP HPH | lld:pubmed |
| pubmed-article:1314824 | pubmed:author | pubmed-author:StephensJ MJM | lld:pubmed |
| pubmed-article:1314824 | pubmed:author | pubmed-author:MalterJ SJS | lld:pubmed |
| pubmed-article:1314824 | pubmed:author | pubmed-author:CarterB ZBZ | lld:pubmed |
| pubmed-article:1314824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1314824 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1314824 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:1314824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1314824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1314824 | pubmed:pagination | 8336-41 | lld:pubmed |
| pubmed-article:1314824 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1314824 | pubmed:meshHeading | pubmed-meshheading:1314824-... | lld:pubmed |
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| pubmed-article:1314824 | pubmed:meshHeading | pubmed-meshheading:1314824-... | lld:pubmed |
| pubmed-article:1314824 | pubmed:meshHeading | pubmed-meshheading:1314824-... | lld:pubmed |
| pubmed-article:1314824 | pubmed:meshHeading | pubmed-meshheading:1314824-... | lld:pubmed |
| pubmed-article:1314824 | pubmed:meshHeading | pubmed-meshheading:1314824-... | lld:pubmed |
| pubmed-article:1314824 | pubmed:meshHeading | pubmed-meshheading:1314824-... | lld:pubmed |
| pubmed-article:1314824 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1314824 | pubmed:articleTitle | Tumor necrosis factor alpha-induced glucose transporter (GLUT-1) mRNA stabilization in 3T3-L1 preadipocytes. Regulation by the adenosine-uridine binding factor. | lld:pubmed |
| pubmed-article:1314824 | pubmed:affiliation | Department of Biochemistry, School of Medicine, East Carolina University, Greenville, North Carolina 27858. | lld:pubmed |
| pubmed-article:1314824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1314824 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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