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| pubmed-article:1314587 | pubmed:dateCreated | 1992-5-20 | lld:pubmed |
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| pubmed-article:1314587 | pubmed:abstractText | A human BK-2 bradykinin receptor was cloned from the lung fibroblast cell line CCD-16Lu. The cDNA clone encodes a 364 amino acid protein that has the characteristics of a seven transmembrane domain G-protein coupled receptor. The predicted amino acid sequence of the human BK-2 receptor is 81% identical to the smooth muscle rat BK-2 receptor (1). Transfection of the human BK-2 receptor cDNA into COS-7 cells results in the expression of high levels of specific BK binding sites. Saturation binding analysis indicates that the human BK-2 receptor expressed in COS-7 cells binds BK with a KD of 0.13 nM. Pharmacological characterization of the expressed BK receptor is consistent with the cDNA encoding a receptor of the BK-2 subtype. The BK-2 receptor antagonist Hoe 140 (2), D-Arg0[Hyp3, Thi5, D-Tic7, Oic8]BK has a high affinity (IC50 = 65 pM) for the cloned human receptor. The tissue distribution of the human BK-2 receptor was analyzed by competitive PCR with human tissue cDNA and is similar to that determined for the BK-2 receptor in the rat. | lld:pubmed |
| pubmed-article:1314587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1314587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314587 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1314587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1314587 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1314587 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:1314587 | pubmed:author | pubmed-author:StraderC DCD | lld:pubmed |
| pubmed-article:1314587 | pubmed:author | pubmed-author:YoungG SGS | lld:pubmed |
| pubmed-article:1314587 | pubmed:author | pubmed-author:HoweR FRF | lld:pubmed |
| pubmed-article:1314587 | pubmed:author | pubmed-author:RansomR WRW | lld:pubmed |
| pubmed-article:1314587 | pubmed:author | pubmed-author:BorkowskiJ... | lld:pubmed |
| pubmed-article:1314587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1314587 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1314587 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:1314587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1314587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1314587 | pubmed:pagination | 260-8 | lld:pubmed |
| pubmed-article:1314587 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1314587 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1314587 | pubmed:articleTitle | Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. | lld:pubmed |
| pubmed-article:1314587 | pubmed:affiliation | Merck Research Laboratories, Department of Molecular Pharmacology and Biochemistry, Rahway, N.J. 07065. | lld:pubmed |
| pubmed-article:1314587 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1314587 | pubmed:publicationType | Comparative Study | lld:pubmed |
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