Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-5-11
pubmed:abstractText
Seventeen nodal lymphomas (originally diagnosed as T-cell lymphomas based on histological features and immunohistochemical staining results) were studied for the presence of Epstein-Barr virus (EBV) genome, and the results correlated with immunoglobulin and T-cell receptor gene rearrangement analyses performed on the same tissue samples. All four EBV positive cases had clonal rearrangement of the joining region of the immunoglobulin heavy chain (IgJH) gene without clonal T-cell receptor beta-chain (TCR beta) gene rearrangement. Of these, two cases also showed clonally rearranged light chain gene, and they were reclassified as T-cell rich B-cell lymphomas (TRBL). The other two cases lacked clonal kappa or lambda light chain rearrangement and they were reclassified as T-cell rich lymphomas of probable B lineage, based on their isolated IgJH clonal rearrangement. These B-cell lymphomas may be easily misdiagnosed as T-cell lymphomas owing to the presence of an abundant reactive T-cell infiltrate masking the tumor population. The florid T-cell reaction may represent an unusual host response towards a clonal proliferation of EBV bearing B cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-1967431, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-1979042, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2161617, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2164775, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2169858, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2210727, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2223650, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2425318, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2479554, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2536894, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2538681, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2546633, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2591944, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2675317, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2682665, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2784637, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2821199, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2821817, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2830541, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2843672, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-2893097, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-3022942, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-3023050, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-3258126, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-3287959, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-3805286, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-3875393, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-6198355, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-6272971, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-6273747, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-6276389, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-6334237, http://linkedlifedata.com/resource/pubmed/commentcorrection/1314029-6416836
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
981-9
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Clonal Epstein-Barr virus genome in T-cell-rich lymphomas of B or probable B lineage.
pubmed:affiliation
Department of Pathology, University of Hong Kong, Queen Mary Hospital.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't