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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-5-7
|
| pubmed:abstractText |
Phosphatidylinositol-specific phospholipase C (PIPLC) from Bacillus thuringiensis (0.11 units per ml) inhibited growth of IC-Sofia carcinoma cell line in culture by 64%. The growth of transplanted carcinoma in hamsters was also inhibited by 29% at a dose of 4.9 units of PIPLC/kg animal/day. In addition, degeneration processes and a significant fibrosis of the tumour occurred. The functional, clinical, biochemical and haematological parameters studied were consistent with the established antitumour effect in vivo.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0041-0101
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
187-95
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1313607-Animals,
pubmed-meshheading:1313607-Bacillus thuringiensis,
pubmed-meshheading:1313607-Cell Division,
pubmed-meshheading:1313607-Cricetinae,
pubmed-meshheading:1313607-Male,
pubmed-meshheading:1313607-Mesocricetus,
pubmed-meshheading:1313607-Neoplasm Transplantation,
pubmed-meshheading:1313607-Phosphatidylinositol Diacylglycerol-Lyase,
pubmed-meshheading:1313607-Phosphoinositide Phospholipase C,
pubmed-meshheading:1313607-Phosphoric Diester Hydrolases,
pubmed-meshheading:1313607-Tumor Cells, Cultured
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Effect of phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis on solid spinocellular carcinoma.
|
| pubmed:affiliation |
Department of Physiology, Institute of Medicine, Plovdiv, Bulgaria.
|
| pubmed:publicationType |
Journal Article
|