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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-5-4
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pubmed:abstractText |
Platelet activation by thrombin is critical for hemostasis and thrombosis. Structure-function studies with a recently cloned platelet thrombin receptor suggest that a hirudin-like domain in the receptor's extracellular amino terminal extension is a thrombin-binding determinant important for receptor activation. We now report that a peptide antiserum to this domain is a potent and specific antagonist of thrombin-induced platelet activation. This study demonstrates that the cloned platelet thrombin receptor is necessary for platelet activation by thrombin, and provides a strategy for developing blocking monoclonal antibodies of potential therapeutic value.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-1054489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-1309820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-1672265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-1717851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-2661588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-2898786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-330568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-3362867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-3471149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-418063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-4213668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-6836310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1313452-986310
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1350-3
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1313452-Amino Acid Sequence,
pubmed-meshheading:1313452-Animals,
pubmed-meshheading:1313452-Female,
pubmed-meshheading:1313452-Hirudins,
pubmed-meshheading:1313452-Humans,
pubmed-meshheading:1313452-Molecular Sequence Data,
pubmed-meshheading:1313452-Platelet Activation,
pubmed-meshheading:1313452-Receptors, Cell Surface,
pubmed-meshheading:1313452-Receptors, Thrombin,
pubmed-meshheading:1313452-Thrombin,
pubmed-meshheading:1313452-Xenopus laevis
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pubmed:year |
1992
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pubmed:articleTitle |
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.
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pubmed:affiliation |
Department of Laboratory Medicine, University of California, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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