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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-4-20
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pubmed:abstractText |
Antibody-capture enzyme-linked immunosorbent assays (AC-ELISA) which use enzyme-labelled antigen were developed for detection of varicella-zoster virus-(VZV) specific IgM, IgA and IgG antibody in patients with varicella or herpes zoster and in sera from healthy individuals. All 18 patients with varicella developed a VZV-IgM and a VZV-IgG response, 17 also a VZV-IgA response. In contrast, all 19 patients with herpes zoster were shown to be positive for VZV-IgA whereas only 13 of these reacted positively for VZV-IgM. A VZV-IgM response was detected in only two sera from 100 healthy individuals and an IgA response in only one. The presence of virus-specific IgA and IgG in the cerebrospinal fluid as determined by AC-ELISA was a useful indicator of VZV infection of the central nervous system. By AC-ELISA, VZV-IgG was detected predominantly in sera from patients with acute or recent VZV infection. Only 14 sera from 100 healthy individuals were positive for VZV-IgG by AC-ELISA, whereas all were positive by an indirect ELISA. These results indicate that AC-ELISA's may be useful assays for determination for acute or recurrent VZV infection, but are not suitable for determination of past infection with this virus.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-169308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-219110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-225390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-2983012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-3011851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-3031108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-3402547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-3760134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-4566017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6248482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6255087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6260833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6263941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6271923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6292875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6296180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6310001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6313743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6315766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6330163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-6409510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-7016893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312479-7298297
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0950-2688
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-74
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1312479-Acute Disease,
pubmed-meshheading:1312479-Antibodies, Viral,
pubmed-meshheading:1312479-Chickenpox,
pubmed-meshheading:1312479-Dose-Response Relationship, Immunologic,
pubmed-meshheading:1312479-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1312479-Evaluation Studies as Topic,
pubmed-meshheading:1312479-Follow-Up Studies,
pubmed-meshheading:1312479-Herpes Zoster,
pubmed-meshheading:1312479-Herpesvirus 3, Human,
pubmed-meshheading:1312479-Humans,
pubmed-meshheading:1312479-Immunoglobulin A,
pubmed-meshheading:1312479-Immunoglobulin G,
pubmed-meshheading:1312479-Immunoglobulin M,
pubmed-meshheading:1312479-Immunoglobulins,
pubmed-meshheading:1312479-Meningoencephalitis,
pubmed-meshheading:1312479-Predictive Value of Tests,
pubmed-meshheading:1312479-Recurrence
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pubmed:year |
1992
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pubmed:articleTitle |
Antibody-capture enzyme-linked immunosorbent assays that use enzyme-labelled antigen for detection of virus-specific immunoglobulin M, A and G in patients with varicella or herpes zoster.
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pubmed:affiliation |
Department of Medical Microbiology, University of Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article
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