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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-6-23
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pubmed:abstractText |
The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:geneSymbol |
Lyp
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1303251-Animals,
pubmed-meshheading:1303251-Base Sequence,
pubmed-meshheading:1303251-Chromosome Mapping,
pubmed-meshheading:1303251-Crosses, Genetic,
pubmed-meshheading:1303251-DNA,
pubmed-meshheading:1303251-Diabetes Mellitus, Type 1,
pubmed-meshheading:1303251-Female,
pubmed-meshheading:1303251-Genes, Recessive,
pubmed-meshheading:1303251-Genetic Linkage,
pubmed-meshheading:1303251-Genetic Markers,
pubmed-meshheading:1303251-Lymphopenia,
pubmed-meshheading:1303251-Major Histocompatibility Complex,
pubmed-meshheading:1303251-Male,
pubmed-meshheading:1303251-Molecular Sequence Data,
pubmed-meshheading:1303251-Neuropeptide Y,
pubmed-meshheading:1303251-Rats,
pubmed-meshheading:1303251-Rats, Inbred BB,
pubmed-meshheading:1303251-Rats, Inbred F344,
pubmed-meshheading:1303251-Rats, Inbred Lew,
pubmed-meshheading:1303251-T-Lymphocytes
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pubmed:year |
1992
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pubmed:articleTitle |
Genetic dissection of autoimmune type I diabetes in the BB rat.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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