| pubmed-article:1299132 | pubmed:abstractText | The effect of serotonin, Met- and Leu-enkephalin was studied on the dialysed neurons of Helix pomatia L. Both the Ca- and K-currents were modulated by the above agents. Two types of neurons could be distinguished by their response to serotonin in the case of the voltage activated Ca-current. One group responded by increasing the inward Ca-current, others by decreasing it. Met-enkephalin decreased the Ca-current on every studied neuron, while Leu-enkephalin had modulatory action to both directions. Opiate peptides and serotonin showed a dose-dependent effect, but had different threshold concentrations. The peptides and serotonin also influenced the voltage activated transient and delayed K-currents. Serotonin increased the K-current, while Met-enkephalin decreased it, and Leu-enkephalin could either decrease or increase it. The variations on the response to serotonin and the opiate peptides on non-identified dialysed neurons of Helix can be explained by the presence of different receptors on the neurons used. | lld:pubmed |
