Linked Life Data

12984

Source:http://linkedlifedata.com/resource/pubmed/id/12984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-3-31
pubmed:abstractText
The activity of single neurons in the vestibular neuronal complex of midcollicular decerebrate, decerebellectomized cats were recorded and their responsiveness to iontophoretically applied histamine and other agents determined. The majority of the cells tested were inhibited by iontophoresis of histamine while 24% were excited by this agent. Neurons exhibiting inhibitory responses were widely distributed throughout the four vestibular nuclei and adjacent reticular formation whereas excitatory responses to histamine were obtained mainly in the region of the lateral vestibular nucleus. The H2-receptor blocking agents metiamide and cimetidine were examined as to their actions on spontaneously firing cells and cells affected by histamine. Metiamide was selective in blocking histamine-induced inhibition but not excitation while cimetidine was ineffective in blocking either response. These results suggest that histamine has both inhibitory and excitatory actions on brain stem neurons and metiamide is an effective antagonist of histamine-induced inhibition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Iontophoretic studies of histamine and histamine antagonists in the feline vestibular nuclei.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.