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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-9-11
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pubmed:abstractText |
(1) The effects of the selective 5-HT7 receptor antagonists SB-269970 (3-300 microg kg-1; n=5-6) and SB-656104 (30 microg kg-1; n=5) administered centrally (i.c.v.) were investigated on the 'micturition reflex' in the urethane anaesthetized female rat. (2) In cystometric recordings, SB-269970 caused significant increases in volume of 58+/-15 and 138+/-33% and pressure of 140+/-46 and 149+/-60% thresholds at 10 and 30 microg kg-1. These changes were associated with significant decreases in distension-induced bladder contraction of 62+/-14 and 60+/-11%, respectively. However, there was no change in residual volume. At the higher doses, SB-269970 blocked the micturition reflex. SB-656104 had similar effects to SB-269970 but in addition significantly increased the residual volume. (3) SB-269970 (10 microg kg-1; n=5) given i.v. had no effect on the micturition reflex. (4) SB-269970 (30 microg kg-1; n=4) given intrathecally (i.t.) had no effect on micturition reflex, although the selective 5-HT1A receptor antagonist WAY-100635 given i.t. after SB-269970 caused a significant increase in the volume threshold. (5) Using an isovolumetric method in which urethral changes were measured, SB-269970 (30 microg kg-1; n=4; i.c.v.) failed to have any effect on these urethral-evoked changes although they significantly reduced the amplitude of the bladder contraction. (6) These data demonstrate that 5-HT7 receptors located supraspinally in the rat are involved in the control of micturition.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-10454502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-10462127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-10669560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-10821781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-10822046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-11325795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-11691870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-11750788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-11750917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-11888546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-12023943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-12137933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-12392747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-12411418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-12444493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-12812993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-1352548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-14677603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-2207497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-2604003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-2947981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-4830420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-7647964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-8111640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-8350989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-8646411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-8646420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-9176360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-9666094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-9680249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12967934-9786516
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12967934-Anesthesia,
pubmed-meshheading:12967934-Anesthetics, Intravenous,
pubmed-meshheading:12967934-Animals,
pubmed-meshheading:12967934-Female,
pubmed-meshheading:12967934-Muscle Contraction,
pubmed-meshheading:12967934-Rats,
pubmed-meshheading:12967934-Rats, Sprague-Dawley,
pubmed-meshheading:12967934-Receptors, Serotonin,
pubmed-meshheading:12967934-Reflex,
pubmed-meshheading:12967934-Serotonin Antagonists,
pubmed-meshheading:12967934-Urinary Bladder,
pubmed-meshheading:12967934-Urination
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pubmed:year |
2003
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pubmed:articleTitle |
Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats.
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pubmed:affiliation |
Department of Pharmacology, University College London, Royal Free Campus, Hampstead, London NW3 2PF.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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