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rdf:type |
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lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0030685,
umls-concept:C0043210,
umls-concept:C0079189,
umls-concept:C0085295,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1516048,
umls-concept:C1519658,
umls-concept:C1533691,
umls-concept:C1963578
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pubmed:issue |
4-5
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|
pubmed:dateCreated |
2003-9-11
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|
pubmed:abstractText |
It is well known that the acceptance of the fetoplacental unit in human pregnancy requires maternal immune tolerance, which is thought to be regulated locally by the placenta. Therefore an anti-inflammatory cytokine such as IL-10 plays a critical role in different pregnancy disorders including preeclampsia. In the present study, we examined the expression of both proinflammatory (TNF-alpha, IL-1beta, IL-2) and immunoregulatory (IL-6, IL-10) cytokines from normal term and preeclamptic patients in human trophoblast cultures.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
1043-4666
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12967647-Adolescent,
pubmed-meshheading:12967647-Adult,
pubmed-meshheading:12967647-Analysis of Variance,
pubmed-meshheading:12967647-Blood Pressure,
pubmed-meshheading:12967647-Cells, Cultured,
pubmed-meshheading:12967647-Cytokines,
pubmed-meshheading:12967647-Female,
pubmed-meshheading:12967647-Humans,
pubmed-meshheading:12967647-Interleukin-1,
pubmed-meshheading:12967647-Interleukin-10,
pubmed-meshheading:12967647-Interleukin-2,
pubmed-meshheading:12967647-Interleukin-6,
pubmed-meshheading:12967647-Pre-Eclampsia,
pubmed-meshheading:12967647-Pregnancy,
pubmed-meshheading:12967647-Pregnancy Trimester, Third,
pubmed-meshheading:12967647-Proteinuria,
pubmed-meshheading:12967647-Trophoblasts,
pubmed-meshheading:12967647-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Preeclamptic women are deficient of interleukin-10 as assessed by cytokine release of trophoblast cells in vitro.
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pubmed:affiliation |
Department of Gynecology and Obstetrics, University of Düsseldorf, 40001 Düsseldorf, Germany. daniel.rein@ccc.uab.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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