Linked Life Data

12960773

Source:http://linkedlifedata.com/resource/pubmed/id/12960773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-9-8
pubmed:abstractText
It is widely accepted that nicotine is the active ingredient of tobacco smoke that promotes tobacco dependence. Nicotine interacts with several subtypes of nicotinic acetylcholine receptors (nAChRs). In brain, it primarily targets nAChRs that contain beta2 and alpha4 subunits in combination and those composed of solely alpha7 subunits. The present study tested whether operantly trained rats would self-administer a ligand active at beta2-containing (i.e. not alpha7) nAChRs. Male Sprague-Dawley rats were trained to lever press for i.v. cocaine self-administration. After 2 weeks of cocaine washout, rats were given operant access to 5-iodo-A-85380 (5IA), a beta2-selective nAChR ligand, in daily 1 h sessions. The rats rapidly developed a stable level of 5IA self-administration behavior (unit dose = 5 nmol/kg/infusion). This finding suggests that interaction with beta2-containing nAChRs, without direct involvement of alpha7 receptors, can produce reinforcement and thereby can support self-administration behavior.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1503-5
pubmed:dateRevised
2010-6-4
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Self-administration of 5-iodo-A-85380, a beta2-selective nicotinic receptor ligand, by operantly trained rats.
pubmed:affiliation
Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. xiu.liu@cshs.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't