Linked Life Data

12952020

Source:http://linkedlifedata.com/resource/pubmed/id/12952020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-9-3
pubmed:abstractText
Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the complex nature of the disorder, the binary categorization of individuals as affected or unaffected may be a poor indicator of their underlying genetic susceptibility. Quantitative risk factors, or endophenotypes, that differentiate levels of severity among affected individuals and levels of susceptibility among unaffected individuals, provide one solution to this problem. Genetic studies of such quantitative risk factors in families of probands with alcohol dependence may help to disentangle the complex genetic architecture of this disorder.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0785-3890
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-43
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Quantitative risk factors as indices of alcoholism susceptibility.
pubmed:affiliation
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA. almasy@darwin.sfbr.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review