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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2003-8-27
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pubmed:abstractText |
Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led to significant improvements in the pharmacokinetic profile of these analogues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AminDilipD,
pubmed-author:BiY HYH,
pubmed-author:BilderGlendaG,
pubmed-author:GalzcinskiHelenH,
pubmed-author:HanneyBarbaraB,
pubmed-author:MaguireMartin PMP,
pubmed-author:MyersMichael RMR,
pubmed-author:NeedleSaulS,
pubmed-author:SetzerNatalieN,
pubmed-author:SpadaAlfred PAP,
pubmed-author:ZulliAllisonA
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3091-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12941341-Angioplasty, Balloon, Coronary,
pubmed-meshheading:12941341-Aorta,
pubmed-meshheading:12941341-Cell Division,
pubmed-meshheading:12941341-Coronary Restenosis,
pubmed-meshheading:12941341-Enzyme Inhibitors,
pubmed-meshheading:12941341-Humans,
pubmed-meshheading:12941341-Inhibitory Concentration 50,
pubmed-meshheading:12941341-Muscle, Smooth, Vascular,
pubmed-meshheading:12941341-Phosphorylation,
pubmed-meshheading:12941341-Protein-Tyrosine Kinases,
pubmed-meshheading:12941341-Quinoxalines,
pubmed-meshheading:12941341-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:12941341-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent.
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pubmed:affiliation |
Aventis Pharmaceuticals, Route 202/206, Bridgewater, NJ 08807, USA. myers_michael_r@lilly.com
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pubmed:publicationType |
Journal Article
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