Linked Life Data

12934185

Source:http://linkedlifedata.com/resource/pubmed/id/12934185

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-8-22
pubmed:abstractText
Influenza-associated encephalopathy, a severe neurologic complication of influenza, is being reported more frequently in Japan. We investigated the transcription of cytokine genes in peripheral blood leukocytes and compared patients with influenza and with encephalopathy or febrile convulsions and patients with influenza but without neurologic complications. A quantitative polymerase chain reaction (PCR) revealed that transcription of the interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha genes was up-regulated to a greater extent in patients with encephalopathy than in those without neurologic complications. Plasma IL-6 levels also were higher in patients with encephalopathy, although the difference was marginal. Viral RNA in throat swabs was quantified using a real-time quantitative PCR. The virus load was similar among patients with encephalopathy or febrile convulsions or without neurologic complications. Furthermore, virus load was not correlated with either the transcription of cytokine genes or plasma cytokine concentrations. These results suggest that influenza-associated encephalopathy might be a consequence of systemic immune responses.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
188
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
690-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12934185-Child, pubmed-meshheading:12934185-Child, Preschool, pubmed-meshheading:12934185-Cytokines, pubmed-meshheading:12934185-Encephalitis, Viral, pubmed-meshheading:12934185-Female, pubmed-meshheading:12934185-Humans, pubmed-meshheading:12934185-Infant, pubmed-meshheading:12934185-Influenza, Human, pubmed-meshheading:12934185-Influenza A virus, pubmed-meshheading:12934185-Influenza B virus, pubmed-meshheading:12934185-Interleukin-10, pubmed-meshheading:12934185-Interleukin-6, pubmed-meshheading:12934185-Leukocytes, Mononuclear, pubmed-meshheading:12934185-Male, pubmed-meshheading:12934185-RNA, Viral, pubmed-meshheading:12934185-Seizures, Febrile, pubmed-meshheading:12934185-Tumor Necrosis Factor-alpha, pubmed-meshheading:12934185-Up-Regulation, pubmed-meshheading:12934185-Viral Load
pubmed:year
2003
pubmed:articleTitle
Systemic cytokine responses in patients with influenza-associated encephalopathy.
pubmed:affiliation
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. k-kawada@qa2.so-net.ne.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't