Linked Life Data

12933871

Source:http://linkedlifedata.com/resource/pubmed/id/12933871

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-8-22
pubmed:abstractText
Variant alleles in the mannose-binding lectin (MBL) gene (mbl2) causing low levels of functional MBL are associated with susceptibility to different infections and are common in areas where malaria is endemic. Therefore, we investigated whether MBL variant alleles in 551 children from Ghana were associated with the occurrence and outcome parameters of Plasmodium falciparum malaria and asked whether MBL may function as an opsonin for P. falciparum. No difference in MBL genotype frequency was observed between infected and noninfected children or between children with cerebral malaria and/or severe malarial anemia and children with uncomplicated malaria. However, patients with complicated malaria who were homozygous for MBL variant alleles had significantly higher parasite counts and lower blood glucose levels than their MBL-competent counterparts. Distinct calcium-dependent binding of MBL to the membrane of P. falciparum-infected erythrocytes, which could be inhibited by mannose, was observed. Further characterization revealed that MBL reacted with a P. falciparum glycoprotein identical to the 78-kDa glucose-regulated stress protein of P. falciparum. MBL seems to be a disease modifier in clinical malaria and to function as an opsonin for erythrocytes invaded by P. falciparum and may thus be involved in sequestration of the parasite, which in turn may explain the association between homozygosity for MBL variant alleles and high parasite counts.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10203135, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10213198, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10417178, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10449435, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10524686, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10648014, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10698339, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-10728743, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-11120776, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-11255386, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-11447210, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-11836800, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-11907103, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-11936498, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-12270724, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-1304173, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-1458688, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-1460414, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-1477092, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-1675710, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-1779989, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-1865923, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-2477486, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-2590164, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-3045815, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-3584121, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-388439, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-7524615, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-7564730, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-7673719, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-7707811, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-7818559, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-7935762, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-8206524, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-8729443, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-8961631, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-8961910, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9014910, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9047234, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9087411, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9098426, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9154025, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9584002, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9635949, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9743385, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9806066, http://linkedlifedata.com/resource/pubmed/commentcorrection/12933871-9854050
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5245-53
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...