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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-8-22
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pubmed:abstractText |
Renieramycin J (1), a new tetrahydroisoquinoline alkaloid, has been isolated from a marine sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1 cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The structure of 1 including the absolute stereochemistry was determined by spectroscopic and chemical methods.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1136-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12932144-Alkaloids,
pubmed-meshheading:12932144-Animals,
pubmed-meshheading:12932144-Antineoplastic Agents,
pubmed-meshheading:12932144-Drug Screening Assays, Antitumor,
pubmed-meshheading:12932144-Fibroblasts,
pubmed-meshheading:12932144-Inhibitory Concentration 50,
pubmed-meshheading:12932144-Japan,
pubmed-meshheading:12932144-Molecular Structure,
pubmed-meshheading:12932144-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:12932144-Porifera,
pubmed-meshheading:12932144-Rats,
pubmed-meshheading:12932144-Tetrahydroisoquinolines
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pubmed:year |
2003
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pubmed:articleTitle |
Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp..
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pubmed:affiliation |
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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