Linked Life Data

12930361

Source:http://linkedlifedata.com/resource/pubmed/id/12930361

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-8-21
pubmed:abstractText
Mannan-binding lectin (MBL) triggers complement activation upon binding to microbial surfaces. MBL deficiency has been associated with increased susceptibility to severe bacterial infections. We hypothesized that MBL deficiency may predispose children to Shiga toxin-producing Escherichia coli (STEC) O157:H7 infections and the associated haemolytic uraemic syndrome (HUS). We compared circulating levels of MBL among children with uncomplicated O157:H7 haemorrhagic colitis (HC), patients with O157:H7 HUS, normal and diseases control groups. Circulating MBL concentrations on admission were as follows: 3.22 +/- 2.43 micro g/ml among normal controls (n = 23); 2.90 +/- 2.44 micro g/ml in patients with rotavirus enteritis (n = 10); 2.78 +/- 1.65 micro g/ml in children with HC due to non-STEC bacterial pathogen (n = 15); 2.67 +/- 2.44 micro g/ml in patients with uncomplicated O157:H7 HC (n = 27); 2.80 +/- 2.97 micro g/ml in children with O157:H7 HUS (n = 15); 6.70 +/- 4.49 micro g/ml in patients with chronic renal failure unrelated to O157:H7 infection (n = 6). Higher MBL levels were found in patients with chronic renal failure compared to O157:H7 HC (P < 0.047). However, MBL concentrations <0.5 micro g/ml, which have been associated with MBL deficiency in relation to increased susceptibility to infections, were noted at comparable rates between the different groups (P = NS). Our data does not support that MBL deficiency may predispose to O157:H7 infections nor than the development of diarrhoea associated HUS.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-10215327, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-10639434, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-11414367, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-11530147, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-11530153, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-12372959, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-1395098, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-1436342, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-371879, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-4129358, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-4795545, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-7379368, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-8863868, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-8961631, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-9154025, http://linkedlifedata.com/resource/pubmed/commentcorrection/12930361-9719138
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
360-3
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Mannan-binding lectin in children with Escherichia coli O157:H7 haemmorrhagic colitis and haemolytic uraemic syndrome.
pubmed:affiliation
Department of Paediatrics, Section of Intensive Care Medicine, Section of Haematology and Oncology and Section of Gastroenterology, Sainte-Justine Hospital, Montreal, Canada. fproulx_01@yahoo.ca
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't