12917427

Source:http://linkedlifedata.com/resource/pubmed/id/12917427

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0008396, umls-concept:C0026809, umls-concept:C0062151, umls-concept:C0074129, umls-concept:C0205054, umls-concept:C0205263, umls-concept:C0299583, umls-concept:C0332307, umls-concept:C1413218
pubmed:issue	44
pubmed:dateCreated	2003-10-27
pubmed:abstractText	Cholesterol elimination from the body involves reverse cholesterol transport from peripheral tissues in which the elimination of high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol by the liver and subsequent biliary excretion as free cholesterol and bile acids are important. In situations of peripheral fat and cholesterol accumulation, such as obesity, these pathways may be overloaded, contributing to increased cholesterol deposition. Leptin has an important role in obesity, suppressing food intake and increasing energy expenditure. This hormone, which is absent in genetically obese ob/ob mice, is also thought to be involved in the coordination of lipid excretion pathways, although available data are somewhat inconsistent. We therefore studied the expression of the hepatic HDL receptor, scavenger receptor class B type I (SR-BI), and the LDL receptor as well as the rate-limiting enzyme in bile acid synthesis, cholesterol 7alpha-hydroxylase (Cyp7a1), in leptin-deficient ob/ob mice and their wild-type controls. In ob/ob mice, protein levels of both LDL receptor and SR-BI were reduced, whereas LDL receptor mRNA levels were increased and those of SR-BI were reduced, regardless of challenge with a 2% cholesterol diet. In ob/ob mice, the enzymatic activity and mRNA for Cyp7a1 were reduced, and the increase in response to dietary cholesterol was blunted. Upon short-term (2 days) treatment with leptin, a dose-dependent increase was seen in the SR-BI protein and mRNA, whereas the Cyp7a1 protein and mRNA were reduced. Our findings indicate that leptin is an important regulator of hepatic SR-BI expression and, thus, HDL cholesterol levels, whereas it does not stimulate Cyp7a1 and bile acid synthesis.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985121R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD36, http://linkedlifedata.com/resource/pubmed/chemical/Bile Acids and Salts, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol 7-alpha-Hydroxylase, http://linkedlifedata.com/resource/pubmed/chemical/Leptin, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger, http://linkedlifedata.com/resource/pubmed/chemical/Scarb1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B, http://linkedlifedata.com/resource/pubmed/chemical/leptin receptor, mouse
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0021-9258
pubmed:author	pubmed-author:AngelinBoB, pubmed-author:LundåsenThomasT, pubmed-author:OelsMM, pubmed-author:RudlingMatsM
pubmed:issnType	Print
pubmed:day	31
pubmed:volume	278
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	43224-8
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:12917427-Animals, pubmed-meshheading:12917427-Antigens, CD36, pubmed-meshheading:12917427-Bile Acids and Salts, pubmed-meshheading:12917427-Cholesterol, pubmed-meshheading:12917427-Cholesterol 7-alpha-Hydroxylase, pubmed-meshheading:12917427-Dose-Response Relationship, Drug, pubmed-meshheading:12917427-Leptin, pubmed-meshheading:12917427-Lipoproteins, pubmed-meshheading:12917427-Liver, pubmed-meshheading:12917427-Membrane Proteins, pubmed-meshheading:12917427-Mice, pubmed-meshheading:12917427-Mice, Inbred C57BL, pubmed-meshheading:12917427-Mice, Obese, pubmed-meshheading:12917427-RNA, Messenger, pubmed-meshheading:12917427-Receptors, Immunologic, pubmed-meshheading:12917427-Receptors, Leptin, pubmed-meshheading:12917427-Receptors, Lipoprotein, pubmed-meshheading:12917427-Receptors, Scavenger, pubmed-meshheading:12917427-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12917427-Scavenger Receptors, Class B
pubmed:year	2003
pubmed:articleTitle	Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice.
pubmed:affiliation	Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine and Molecular Nutrition Unit, Center for Nutrition and Toxicology, Novum, Karolinska Institutet at Huddinge University Hospital, S-141 86 Stockholm, Sweden.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't