Source:http://linkedlifedata.com/resource/pubmed/id/12912938
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2003-8-12
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| pubmed:abstractText |
Postradiation sarcoma, a sarcoma developing in a previously irradiated field, is a rare tumor. Surgery appears to be the only curative treatment option. In general the prognosis is poor, and new treatments options are needed. One study reported the expression of KIT receptor tyrosine kinase in two postradiation angiosarcomas. Success of inhibition of KIT in malignant gastrointestinal stromal tumors with imatinib mesylate seems mutation-dependent, with a favorable response in the presence of exon 11 mutations. Experimental Design: We performed a clinical, immunohistochemical, and genetic assessment of postradiation sarcomas, including angiosarcomas. Archival tumor tissue was available from 16 patients diagnosed with a postradiation sarcoma between 1978 and 2001. Data on the first and secondary tumor, treatment, and follow-up was documented. KIT expression was assessed by immunohistochemistry. For comparison, 23 spontaneous soft tissue sarcomas of similar histological types were analyzed. Exon 11 of the c-kit gene was analyzed by direct DNA sequencing.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
1078-0432
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2926-32
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:12912938-Adolescent,
pubmed-meshheading:12912938-Adult,
pubmed-meshheading:12912938-Aged,
pubmed-meshheading:12912938-Dose-Response Relationship, Radiation,
pubmed-meshheading:12912938-Exons,
pubmed-meshheading:12912938-Female,
pubmed-meshheading:12912938-Hemangiosarcoma,
pubmed-meshheading:12912938-Humans,
pubmed-meshheading:12912938-Immunohistochemistry,
pubmed-meshheading:12912938-Infant,
pubmed-meshheading:12912938-Male,
pubmed-meshheading:12912938-Middle Aged,
pubmed-meshheading:12912938-Mutation,
pubmed-meshheading:12912938-Neoplasms, Radiation-Induced,
pubmed-meshheading:12912938-Prognosis,
pubmed-meshheading:12912938-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:12912938-Radiotherapy,
pubmed-meshheading:12912938-Sarcoma,
pubmed-meshheading:12912938-Soft Tissue Neoplasms,
pubmed-meshheading:12912938-Time Factors
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Clinicopathologic assessment of postradiation sarcomas: KIT as a potential treatment target.
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| pubmed:affiliation |
Departments of Surgical Oncology, University Hospital Groningen, 9713 GZ Groningen, the Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|