Linked Life Data

12907787

Source:http://linkedlifedata.com/resource/pubmed/id/12907787

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5634
pubmed:dateCreated
2003-8-8
pubmed:abstractText
The separation of homologous chromosomes during meiosis in eukaryotes is the physical basis of Mendelian inheritance. The core of the meiotic process is a specialized nuclear division (meiosis I) in which homologs pair with each other, recombine, and then segregate from each other. The processes of chromosome alignment and pairing allow for homolog recognition. Reciprocal meiotic recombination ensures meiotic chromosome segregation by converting sister chromatid cohesion into mechanisms that hold homologous chromosomes together. Finally, the ability of sister kinetochores to orient to a single pole at metaphase I allows the separation of homologs to two different daughter cells. Failures to properly accomplish this elegant chromosome dance result in aneuploidy, a major cause of miscarriage and birth defects in human beings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
301
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
785-9
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Chromosome choreography: the meiotic ballet.
pubmed:affiliation
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
pubmed:publicationType
Journal Article, Review