| pubmed-article:12899682 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0071163 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12899682 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12899682 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12899682 | pubmed:dateCreated | 2003-8-5 | lld:pubmed |
| pubmed-article:12899682 | pubmed:abstractText | The role of pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptor (PAC1 receptor) in regulating hypothalamic supraoptic neurones was investigated using PAC1 receptor-deficient male mice (PAC1-/-). The effects of PACAP on [Ca2+]i were investigated in freshly dissociated supraoptic neurones and on the somatodendritic release of vasopressin and oxytocin, examined on intact supraoptic nuclei. In supraoptic neurones from wild-type mice (PAC1+/+), 100 nm PACAP induced an increase in [Ca2+]i and release of vasopressin and oxytocin, whereas in heterozygous (PAC1+/-) and null-mutant mice (PAC1-/-), PACAP was much less effective. PACAP had no effect on these two parameters when applied to isolated neurohypophysial nerve terminals of PAC1+/+ and PAC1-/- mice, and rats. In conclusion, the PAC1 receptor is solely responsible for the PACAP-induced [Ca2+]i signalling and secretion of vasopressin and oxytocin in the somatodendritic region of supraoptic neurones. | lld:pubmed |
| pubmed-article:12899682 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12899682 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12899682 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12899682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12899682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12899682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12899682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12899682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12899682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12899682 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12899682 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12899682 | pubmed:issn | 0953-8194 | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:BockaertJJ | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:AlonsoGG | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:CalayGG | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:WidmerHH | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:ShibuyaII | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:DayanithiGG | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:BrabetPP | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:JamenFF | lld:pubmed |
| pubmed-article:12899682 | pubmed:author | pubmed-author:VacherC-MCM | lld:pubmed |
| pubmed-article:12899682 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12899682 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:12899682 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12899682 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12899682 | pubmed:pagination | 871-81 | lld:pubmed |
| pubmed-article:12899682 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12899682 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12899682 | pubmed:articleTitle | Impaired somatodendritic responses to pituitary adenylate cyclase-activating polypeptide (PACAP) of supraoptic neurones in PACAP type I -receptor deficient mice. | lld:pubmed |
| pubmed-article:12899682 | pubmed:affiliation | UPR 9023-CNRS and UMR 5101-CNRS, CCIPE, Montpellier, France. | lld:pubmed |
| pubmed-article:12899682 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12899682 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11517 | entrezgene:pubmed | pubmed-article:12899682 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12899682 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12899682 | lld:pubmed |
